Title |
3,5-Diiodothyronine: A Novel Thyroid Hormone Metabolite and Potent Modulator of Energy Metabolism
|
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Published in |
Frontiers in endocrinology, July 2018
|
DOI | 10.3389/fendo.2018.00427 |
Pubmed ID | |
Authors |
Rosalba Senese, Pieter de Lange, Giuseppe Petito, Maria Moreno, Fernando Goglia, Antonia Lanni |
Abstract |
Over 30 years of research has demonstrated that 3,5-diiodo-L-thyronine (3,5-T2), an endogenous metabolite of thyroid hormones, exhibits interesting metabolic activities. In rodent models, exogenously administered 3,5-T2 rapidly increases resting metabolic rate and elicits short-term beneficial hypolipidemic effects; however, very few studies have evaluated the effects of endogenous and exogenous T2 in humans. Further analyses on larger cohorts are needed to determine whether 3,5-T2 is a potent additional modulator of energy metabolism. In addition, while several lines of evidence suggest that 3,5-T2 mainly acts through Thyroid hormone receptors (THRs)- independent ways, with mitochondria as a likely cellular target, THRs-mediated actions have also been described. The detailed cellular and molecular mechanisms through which 3,5-T2 elicits a multiplicity of actions remains unknown. Here, we provide an overview of the most recent literature on 3,5-T2 bioactivity with a particular focus on short-term and long-term effects, describing data obtained through in vivo and in vitro approaches in both mammalian and non-mammalian species. |
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United Kingdom | 1 | 11% |
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Members of the public | 8 | 89% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
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Unknown | 55 | 100% |
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Student > Ph. D. Student | 6 | 11% |
Student > Bachelor | 5 | 9% |
Researcher | 5 | 9% |
Student > Postgraduate | 4 | 7% |
Other | 13 | 24% |
Unknown | 14 | 25% |
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Unspecified | 3 | 5% |
Other | 11 | 20% |
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