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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Emerging Role of Non-Coding RNAs in Drug Addiction
|
|---|---|
| Published in |
Frontiers in Genetics, January 2012
|
| DOI | 10.3389/fgene.2012.00106 |
| Pubmed ID | |
| Authors |
Gregory C. Sartor, Georges St. Laurent, Claes Wahlestedt |
| Abstract |
Prolonged drug use causes long-lasting neuroadaptations in reward-related brain areas that contribute to addiction. Despite significant amount of research dedicated to understanding the underlying mechanisms of addiction, the molecular underpinnings remain unclear. At the same time, much of the pervasive transcription that encompasses the human genome occurs in the nervous system and contributes to its heterogeneity and complexity. Recent evidence suggests that non-coding RNAs (ncRNAs) play an important and dynamic role in transcriptional regulation, epigenetic signaling, stress response, and plasticity in the nervous system. Dysregulation of ncRNAs are thought to contribute to many, and perhaps all, neurological disorders, including addiction. Here, we review recent insights in the functional relevance of ncRNAs, including both microRNAs (miRNAs), and long non-coding RNAs, and then illustrate specific examples of ncRNA regulation in the context of drug addiction. We conclude that ncRNAs are importantly involved in the persistent neuroadaptations associated with addiction-related behaviors, and that therapies that target specific ncRNAs may represent new avenues for the treatment of drug addiction. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 2 | 2% |
| France | 1 | 1% |
| Pakistan | 1 | 1% |
| Japan | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 74 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 28% |
| Student > Ph. D. Student | 22 | 27% |
| Student > Master | 7 | 9% |
| Professor | 6 | 7% |
| Professor > Associate Professor | 5 | 6% |
| Other | 10 | 12% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 39% |
| Neuroscience | 16 | 20% |
| Medicine and Dentistry | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Psychology | 3 | 4% |
| Other | 11 | 13% |
| Unknown | 8 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#6,695,819
of 25,261,240 outputs
Outputs from Frontiers in Genetics
#1,924
of 13,605 outputs
Outputs of similar age
#56,455
of 255,655 outputs
Outputs of similar age from Frontiers in Genetics
#47
of 255 outputs
Altmetric has tracked 25,261,240 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 13,605 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,655 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.