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X Demographics
Mendeley readers
Attention Score in Context
| Title |
CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment
|
|---|---|
| Published in |
Frontiers in Genetics, January 2012
|
| DOI | 10.3389/fgene.2012.00270 |
| Pubmed ID | |
| Authors |
Blake C. Ellis, Peter L. Molloy, Lloyd D. Graham |
| Abstract |
CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and displays a very tissue-specific pattern of expression. CRNDE was initially identified as a lncRNA whose expression is highly elevated in colorectal cancer, but it is also upregulated in many other solid tumors and in leukemias. Indeed, CRNDE is the most upregulated lncRNA in gliomas and here, as in other cancers, it is associated with a "stemness" signature. CRNDE is expressed in specific regions within the human and mouse brain; the mouse ortholog is high in induced pluripotent stem cells and increases further during neuronal differentiation. We suggest that CRNDE is a multifunctional lncRNA whose different splice forms provide specific functional scaffolds for regulatory complexes, such as the polycomb repressive complex 2 (PRC2) and CoREST chromatin-modifying complexes, which CRNDE helps pilot to target genes. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 109 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 28% |
| Researcher | 22 | 20% |
| Student > Master | 15 | 14% |
| Student > Bachelor | 8 | 7% |
| Student > Doctoral Student | 6 | 5% |
| Other | 13 | 12% |
| Unknown | 16 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 33% |
| Biochemistry, Genetics and Molecular Biology | 35 | 32% |
| Medicine and Dentistry | 12 | 11% |
| Neuroscience | 4 | 4% |
| Immunology and Microbiology | 3 | 3% |
| Other | 5 | 5% |
| Unknown | 15 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2013.
All research outputs
#13,372,313
of 22,687,320 outputs
Outputs from Frontiers in Genetics
#3,228
of 11,754 outputs
Outputs of similar age
#146,696
of 244,125 outputs
Outputs of similar age from Frontiers in Genetics
#96
of 255 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,754 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,125 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 255 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.