Controlled shortening of the poly(A) tail of mRNAs is the first step in eukaryotic mRNA decay and can also be used for translational inactivation of mRNAs. The CCR4-NOT complex is the most important among a small number of deadenylases, enzymes catalyzing poly(A) tail shortening. Rates of poly(A) shortening differ between mRNAs as the CCR4-NOT complex is recruited to specific mRNAs by means of either sequence-specific RNA binding proteins or miRNAs. This review summarizes our current knowledge concerning the subunit composition and deadenylation activity of the Drosophila CCR4-NOT complex and the mechanisms by which the complex is recruited to particular mRNAs. We discuss genetic data implicating the complex in the regulation of specific mRNAs, in particular in the context of development.
Pharmacology, Toxicology and Pharmaceutical Science
1
<1%
Environmental Science
1
<1%
Other
4
3%
Unknown
28
24%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 May 2014.
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#19,015,492
of 23,577,654 outputs
Outputs from Frontiers in Genetics
#7,397
of 12,604 outputs
Outputs of similar age
#164,808
of 228,002 outputs
Outputs of similar age from Frontiers in Genetics
#98
of 119 outputs
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So far Altmetric has tracked 12,604 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
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