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Changes in variance explained by top SNP windows over generations for three traits in broiler chicken

Overview of attention for article published in Frontiers in Genetics, October 2014
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Title
Changes in variance explained by top SNP windows over generations for three traits in broiler chicken
Published in
Frontiers in Genetics, October 2014
DOI 10.3389/fgene.2014.00332
Pubmed ID
Authors

Breno de Oliveira Fragomeni, Ignacy Misztal, Daniela Lino Lourenco, Ignacio Aguilar, Ronald Okimoto, William M. Muir

Abstract

The purpose of this study was to determine if the set of genomic regions inferred as accounting for the majority of genetic variation in quantitative traits remain stable over multiple generations of selection. The data set contained phenotypes for five generations of broiler chicken for body weight, breast meat, and leg score. The population consisted of 294,632 animals over five generations and also included genotypes of 41,036 single nucleotide polymorphism (SNP) for 4,866 animals, after quality control. The SNP effects were calculated by a GWAS type analysis using single step genomic BLUP approach for generations 1-3, 2-4, 3-5, and 1-5. Variances were calculated for windows of 20 SNP. The top ten windows for each trait that explained the largest fraction of the genetic variance across generations were examined. Across generations, the top 10 windows explained more than 0.5% but less than 1% of the total variance. Also, the pattern of the windows was not consistent across generations. The windows that explained the greatest variance changed greatly among the combinations of generations, with a few exceptions. In many cases, a window identified as top for one combination, explained less than 0.1% for the other combinations. We conclude that identification of top SNP windows for a population may have little predictive power for genetic selection in the following generations for the traits here evaluated.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
United States 1 2%
Colombia 1 2%
Unknown 55 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 17%
Student > Ph. D. Student 9 15%
Student > Doctoral Student 8 14%
Student > Postgraduate 5 8%
Student > Master 5 8%
Other 11 19%
Unknown 11 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 59%
Biochemistry, Genetics and Molecular Biology 5 8%
Veterinary Science and Veterinary Medicine 3 5%
Mathematics 1 2%
Medicine and Dentistry 1 2%
Other 1 2%
Unknown 13 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2014.
All research outputs
#13,920,619
of 22,765,347 outputs
Outputs from Frontiers in Genetics
#3,509
of 11,758 outputs
Outputs of similar age
#127,232
of 253,597 outputs
Outputs of similar age from Frontiers in Genetics
#69
of 117 outputs
Altmetric has tracked 22,765,347 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,758 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,597 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.