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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity
|
|---|---|
| Published in |
Frontiers in Genetics, April 2015
|
| DOI | 10.3389/fgene.2015.00143 |
| Pubmed ID | |
| Authors |
Emilio Cusanelli, Pascal Chartrand |
| Abstract |
Telomeres are dynamic nucleoprotein structures that protect the ends of chromosomes from degradation and activation of DNA damage response. For this reason, telomeres are essential to genome integrity. Chromosome ends are enriched in heterochromatic marks and proper organization of telomeric chromatin is important to telomere stability. Despite their heterochromatic state, telomeres are transcribed giving rise to long noncoding RNAs (lncRNA) called TERRA (telomeric repeat-containing RNA). TERRA molecules play critical roles in telomere biology, including regulation of telomerase activity and heterochromatin formation at chromosome ends. Emerging evidence indicate that TERRA transcripts form DNA-RNA hybrids at chromosome ends which can promote homologous recombination among telomeres, delaying cellular senescence and sustaining genome instability. Intriguingly, TERRA RNA-telomeric DNA hybrids are involved in telomere length homeostasis of telomerase-negative cancer cells. Furthermore, TERRA transcripts play a role in the DNA damage response (DDR) triggered by dysfunctional telomeres. We discuss here recent developments on TERRA's role in telomere biology and genome integrity, and its implication in cancer. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 29% |
| United States | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 71% |
| Scientists | 2 | 29% |
Mendeley readers
The data shown below were compiled from readership statistics for 345 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| India | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 339 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 85 | 25% |
| Researcher | 49 | 14% |
| Student > Master | 49 | 14% |
| Student > Bachelor | 47 | 14% |
| Student > Postgraduate | 16 | 5% |
| Other | 37 | 11% |
| Unknown | 62 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 144 | 42% |
| Agricultural and Biological Sciences | 89 | 26% |
| Medicine and Dentistry | 14 | 4% |
| Chemistry | 13 | 4% |
| Neuroscience | 4 | 1% |
| Other | 14 | 4% |
| Unknown | 67 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 32. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2022.
All research outputs
#1,092,637
of 23,506,079 outputs
Outputs from Frontiers in Genetics
#188
of 12,528 outputs
Outputs of similar age
#14,711
of 265,601 outputs
Outputs of similar age from Frontiers in Genetics
#4
of 120 outputs
Altmetric has tracked 23,506,079 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,528 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.