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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders
|
|---|---|
| Published in |
Frontiers in Genetics, February 2018
|
| DOI | 10.3389/fgene.2018.00029 |
| Pubmed ID | |
| Authors |
Arlene J. George, Yarely C. Hoffiz, Antoinette J. Charles, Ying Zhu, Angela M. Mabb |
| Abstract |
Protein ubiquitination is a posttranslational modification that plays an integral part in mediating diverse cellular functions. The process of protein ubiquitination requires an enzymatic cascade that consists of a ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2) and an E3 ubiquitin ligase (E3). There are an estimated 600-700 E3 ligase genes representing ~5% of the human genome. Not surprisingly, mutations in E3 ligase genes have been observed in multiple neurological conditions. We constructed a comprehensive atlas of disrupted E3 ligase genes in common (CND) and rare neurological diseases (RND). Of the predicted and known human E3 ligase genes, we found ~13% were mutated in a neurological disorder with 83 total genes representing 70 different types of neurological diseases. Of the E3 ligase genes identified, 51 were associated with an RND. Here, we provide an updated list of neurological disorders associated with E3 ligase gene disruption. We further highlight research in these neurological disorders and discuss the advanced technologies used to support these findings. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Spain | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 317 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 317 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 80 | 25% |
| Student > Master | 41 | 13% |
| Student > Bachelor | 31 | 10% |
| Researcher | 25 | 8% |
| Student > Doctoral Student | 18 | 6% |
| Other | 30 | 9% |
| Unknown | 92 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 104 | 33% |
| Agricultural and Biological Sciences | 34 | 11% |
| Neuroscience | 25 | 8% |
| Chemistry | 19 | 6% |
| Medicine and Dentistry | 9 | 3% |
| Other | 30 | 9% |
| Unknown | 96 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2023.
All research outputs
#3,065,483
of 23,539,593 outputs
Outputs from Frontiers in Genetics
#893
of 12,563 outputs
Outputs of similar age
#73,777
of 448,812 outputs
Outputs of similar age from Frontiers in Genetics
#17
of 113 outputs
Altmetric has tracked 23,539,593 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,563 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 448,812 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.