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Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter

Overview of attention for article published in Frontiers in Genetics, May 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

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51 X users

Citations

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287 Mendeley
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Title
Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter
Published in
Frontiers in Genetics, May 2018
DOI 10.3389/fgene.2018.00158
Pubmed ID
Authors

April L. Darling, Vladimir N. Uversky

Abstract

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are functional proteins and domains that devoid stable secondary and/or tertiary structure. IDPs/IDPRs are abundantly present in various proteomes, where they are involved in regulation, signaling, and control, thereby serving as crucial regulators of various cellular processes. Various mechanisms are utilized to tightly regulate and modulate biological functions, structural properties, cellular levels, and localization of these important controllers. Among these regulatory mechanisms are precisely controlled degradation and different posttranslational modifications (PTMs). Many normal cellular processes are associated with the presence of the right amounts of precisely activated IDPs at right places and in right time. However, wrecked regulation of IDPs/IDPRs might be associated with various human maladies, ranging from cancer and neurodegeneration to cardiovascular disease and diabetes. Pathogenic transformations of IDPs/IDPRs are often triggered by altered PTMs. This review considers some of the aspects of IDPs/IDPRs and their normal and aberrant regulation by PTMs.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 287 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 287 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 79 28%
Researcher 35 12%
Student > Master 35 12%
Student > Bachelor 30 10%
Professor 9 3%
Other 29 10%
Unknown 70 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 105 37%
Agricultural and Biological Sciences 42 15%
Chemistry 25 9%
Engineering 5 2%
Immunology and Microbiology 4 1%
Other 28 10%
Unknown 78 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2021.
All research outputs
#1,406,713
of 26,175,232 outputs
Outputs from Frontiers in Genetics
#257
of 13,867 outputs
Outputs of similar age
#29,294
of 343,561 outputs
Outputs of similar age from Frontiers in Genetics
#7
of 129 outputs
Altmetric has tracked 26,175,232 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,867 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.