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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells
|
|---|---|
| Published in |
Frontiers in Genetics, August 2018
|
| DOI | 10.3389/fgene.2018.00296 |
| Pubmed ID | |
| Authors |
Ivan Jelenić, Anna Selmecki, Liedewij Laan, Nenad Pavin |
| Abstract |
Faithful chromosome segregation, driven by the mitotic spindle, is essential for organismal survival. Neopolyploid cells from diverse species exhibit a significant increase in mitotic errors relative to their diploid progenitors, resulting in chromosome nondisjunction. In the model system Saccharomyces cerevisiae, the rate of chromosome loss in haploid and diploid cells is measured to be one thousand times lower than the rate of loss in isogenic tetraploid cells. Currently it is unknown what constrains the number of chromosomes that can be segregated with high fidelity in an organism. Here we developed a simple mathematical model to study how different rates of chromosome loss in cells with different ploidy can arise from changes in (1) spindle dynamics and (2) a maximum duration of mitotic arrest, after which cells enter anaphase. We apply this model to S. cerevisiae to show that this model can explain the observed rates of chromosome loss in S. cerevisiae cells of different ploidy. Our model describes how small increases in spindle assembly time can result in dramatic differences in the rate of chromosomes loss between cells of increasing ploidy and predicts the maximum duration of mitotic arrest. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 9% |
| Unknown | 20 | 91% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 12 | 55% |
| Members of the public | 9 | 41% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 32% |
| Researcher | 6 | 24% |
| Student > Bachelor | 3 | 12% |
| Student > Doctoral Student | 2 | 8% |
| Student > Master | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 52% |
| Agricultural and Biological Sciences | 4 | 16% |
| Immunology and Microbiology | 2 | 8% |
| Engineering | 2 | 8% |
| Unknown | 4 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2018.
All research outputs
#2,974,494
of 26,454,856 outputs
Outputs from Frontiers in Genetics
#741
of 13,992 outputs
Outputs of similar age
#55,539
of 344,464 outputs
Outputs of similar age from Frontiers in Genetics
#19
of 172 outputs
Altmetric has tracked 26,454,856 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,992 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,464 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 172 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.