Title |
Current understanding of the Trypanosoma cruzi-cardiomyocyte interaction
|
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Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00327 |
Pubmed ID | |
Authors |
Claudia M. Calvet, Tatiana G. Melo, Luciana R. Garzoni, Francisco O. R. Oliveira, Dayse T. Silva Neto, N. S. L. Maria, L. Meirelles, Mirian C. S. Pereira |
Abstract |
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits multiple strategies to ensure its establishment and persistence in the host. Although this parasite has the ability to infect different organs, heart impairment is the most frequent clinical manifestation of the disease. Advances in knowledge of T. cruzi-cardiomyocyte interactions have contributed to a better understanding of the biological events involved in the pathogenesis of Chagas disease. This brief review focuses on the current understanding of molecules involved in T. cruzi-cardiomyocyte recognition, the mechanism of invasion, and on the effect of intracellular development of T. cruzi on the structural organization and molecular response of the target cell. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 2% |
Germany | 1 | 1% |
Colombia | 1 | 1% |
United Kingdom | 1 | 1% |
United States | 1 | 1% |
Unknown | 82 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 18% |
Student > Master | 15 | 17% |
Student > Ph. D. Student | 14 | 16% |
Student > Doctoral Student | 11 | 13% |
Student > Bachelor | 10 | 11% |
Other | 11 | 13% |
Unknown | 11 | 13% |
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Agricultural and Biological Sciences | 34 | 39% |
Biochemistry, Genetics and Molecular Biology | 16 | 18% |
Immunology and Microbiology | 11 | 13% |
Veterinary Science and Veterinary Medicine | 4 | 5% |
Medicine and Dentistry | 4 | 5% |
Other | 7 | 8% |
Unknown | 12 | 14% |