Title |
New insights for C5a and C5a receptors in sepsis
|
---|---|
Published in |
Frontiers in immunology, January 2012
|
DOI | 10.3389/fimmu.2012.00368 |
Pubmed ID | |
Authors |
Chunguang Yan, Hongwei Gao |
Abstract |
The complement system plays a central role in inflammation and immunity. Among the complement activation products, C5a is one of the most potent inflammatory peptides with a broad spectrum of functions. There is strong evidence for complement activation including elevated plasma level of C5a in humans and animals with sepsis. C5a exerts its effects through the C5a receptors. Of the two receptors that bind C5a, the C5aR (CD88) is known to mediate signaling activity, whereas the function of another C5a binding receptor, C5L2, remains largely unknown. Here, we review the critical role of C5a in sepsis and summarize evidence indicating that both C5aR and C5L2 act as regulating receptors for C5a during sepsis. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 1% |
Romania | 1 | 1% |
Unknown | 80 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 22% |
Student > Master | 16 | 20% |
Researcher | 10 | 12% |
Student > Postgraduate | 4 | 5% |
Other | 4 | 5% |
Other | 11 | 13% |
Unknown | 19 | 23% |
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Medicine and Dentistry | 17 | 21% |
Biochemistry, Genetics and Molecular Biology | 8 | 10% |
Immunology and Microbiology | 8 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 9 | 11% |
Unknown | 20 | 24% |