Title |
AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
|
---|---|
Published in |
Frontiers in immunology, January 2013
|
DOI | 10.3389/fimmu.2012.00401 |
Pubmed ID | |
Authors |
Aadra P. Bhatt, Blossom Damania |
Abstract |
As an obligate intracellular parasite, Kaposi sarcoma-associated herpesvirus (KSHV) relies on the host cell machinery to meet its needs for survival, viral replication, production, and dissemination of progeny virions. KSHV is a gammaherpesvirus that is associated with three different malignancies: Kaposi sarcoma (KS), and two B cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease. KSHV viral proteins modulate the cellular phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway, which is a ubiquitous pathway that also controls B lymphocyte proliferation and development. We review the mechanisms by which KSHV manipulates the PI3K/AKT/mTOR pathway, with a specific focus on B cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Switzerland | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 1% |
Korea, Republic of | 1 | 1% |
Unknown | 69 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 18% |
Student > Master | 9 | 13% |
Student > Bachelor | 6 | 8% |
Researcher | 6 | 8% |
Student > Doctoral Student | 5 | 7% |
Other | 13 | 18% |
Unknown | 19 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 25% |
Agricultural and Biological Sciences | 14 | 20% |
Medicine and Dentistry | 8 | 11% |
Immunology and Microbiology | 6 | 8% |
Unspecified | 2 | 3% |
Other | 3 | 4% |
Unknown | 20 | 28% |