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AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV

Overview of attention for article published in Frontiers in immunology, January 2013
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Title
AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV
Published in
Frontiers in immunology, January 2013
DOI 10.3389/fimmu.2012.00401
Pubmed ID
Authors

Aadra P. Bhatt, Blossom Damania

Abstract

As an obligate intracellular parasite, Kaposi sarcoma-associated herpesvirus (KSHV) relies on the host cell machinery to meet its needs for survival, viral replication, production, and dissemination of progeny virions. KSHV is a gammaherpesvirus that is associated with three different malignancies: Kaposi sarcoma (KS), and two B cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease. KSHV viral proteins modulate the cellular phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway, which is a ubiquitous pathway that also controls B lymphocyte proliferation and development. We review the mechanisms by which KSHV manipulates the PI3K/AKT/mTOR pathway, with a specific focus on B cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Korea, Republic of 1 1%
Unknown 69 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 18%
Student > Master 9 13%
Student > Bachelor 6 8%
Researcher 6 8%
Student > Doctoral Student 5 7%
Other 13 18%
Unknown 19 27%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 25%
Agricultural and Biological Sciences 14 20%
Medicine and Dentistry 8 11%
Immunology and Microbiology 6 8%
Unspecified 2 3%
Other 3 4%
Unknown 20 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2019.
All research outputs
#20,125,075
of 25,604,262 outputs
Outputs from Frontiers in immunology
#22,896
of 32,042 outputs
Outputs of similar age
#222,463
of 290,097 outputs
Outputs of similar age from Frontiers in immunology
#241
of 503 outputs
Altmetric has tracked 25,604,262 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32,042 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,097 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.