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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Generation and Function of Induced Regulatory T Cells
|
|---|---|
| Published in |
Frontiers in immunology, January 2013
|
| DOI | 10.3389/fimmu.2013.00152 |
| Pubmed ID | |
| Authors |
Erica G. Schmitt, Calvin B. Williams |
| Abstract |
CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, "natural" Treg (nTreg) cells that develop in the thymus, and "induced" Treg (iTreg) cells that arise in the periphery from CD4(+) Foxp3(-) conventional T cells and can be generated in vitro. Previous work has established that both subsets are required for immunological tolerance. Additionally, in vitro-derived iTreg cells can reestablish tolerance in situations where Treg cells are decreased or defective. This review will focus on iTreg cells, drawing comparisons to nTreg cells when possible. We discuss the molecular mechanisms of iTreg cell induction, both in vivo and in vitro, review the Foxp3-dependent and -independent transcriptional landscape of iTreg cells, and examine the proposed suppressive mechanisms utilized by each Treg cell subset. We also compare the T cell receptor repertoire of the Treg cell subsets, discuss inflammatory conditions where iTreg cells are generated or have been used for treatment, and address the issue of iTreg cell stability. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 397 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 1% |
| Germany | 2 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Mexico | 1 | <1% |
| France | 1 | <1% |
| Denmark | 1 | <1% |
| Argentina | 1 | <1% |
| Japan | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 383 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 83 | 21% |
| Researcher | 56 | 14% |
| Student > Bachelor | 53 | 13% |
| Student > Master | 51 | 13% |
| Student > Doctoral Student | 21 | 5% |
| Other | 48 | 12% |
| Unknown | 85 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 84 | 21% |
| Immunology and Microbiology | 78 | 20% |
| Biochemistry, Genetics and Molecular Biology | 60 | 15% |
| Medicine and Dentistry | 54 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 3% |
| Other | 23 | 6% |
| Unknown | 88 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 95. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2023.
All research outputs
#445,973
of 25,373,627 outputs
Outputs from Frontiers in immunology
#415
of 31,516 outputs
Outputs of similar age
#3,060
of 288,991 outputs
Outputs of similar age from Frontiers in immunology
#3
of 503 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,516 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 288,991 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 503 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.