Title |
Serum microRNAs as Biomarkers of Human Lymphocyte Activation in Health and Disease
|
---|---|
Published in |
Frontiers in immunology, January 2014
|
DOI | 10.3389/fimmu.2014.00043 |
Pubmed ID | |
Authors |
Paola de Candia, Anna Torri, Massimiliano Pagani, Sergio Abrignani |
Abstract |
Induction of the adaptive immune system is evaluated mostly by assessment of serum antibody titers and T lymphocyte responses in peripheral blood, although T and B cell activation occurs in lymphoid tissues. In recent years, the release of microRNAs (miRNAs) in the extra-cellular environment has been exploited to assess cell functions at distance via measurement of serum miRNAs. Activated lymphocytes release a large amount of nano-sized vesicles (exosomes), containing miRNA, however there are insufficient data to determine whether this phenomenon is reflected in modulation of serum miRNAs. Interestingly, miRNA signatures of CD4(+) T cell-derived exosomes are substantially different from intracellular miRNA signatures of the same cells. We have recently identified serum circulating miR-150 as a sensor of general lymphocyte activation and we strongly believe that miRNAs differentially released by specific CD4(+) effector T cell subsets (Th1, Th2, Th17, and Treg) may serve as serum biomarkers of their elicitation in lymphoid tissues but also in damaged tissues, potentially providing clinically relevant information about the nature of immune responses in health and disease. |
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Unknown | 1 | 100% |
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Mendeley readers
Geographical breakdown
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Japan | 1 | 1% |
Spain | 1 | 1% |
Netherlands | 1 | 1% |
Ireland | 1 | 1% |
Unknown | 82 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 24 | 28% |
Student > Ph. D. Student | 18 | 21% |
Student > Master | 6 | 7% |
Student > Bachelor | 5 | 6% |
Professor | 4 | 5% |
Other | 10 | 12% |
Unknown | 19 | 22% |
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Medicine and Dentistry | 12 | 14% |
Immunology and Microbiology | 9 | 10% |
Veterinary Science and Veterinary Medicine | 1 | 1% |
Other | 4 | 5% |
Unknown | 24 | 28% |