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Regulatory T Cells as Immunotherapy

Overview of attention for article published in Frontiers in immunology, January 2014
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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6 X users
patent
1 patent
reddit
1 Redditor

Citations

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161 Dimensions

Readers on

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256 Mendeley
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Title
Regulatory T Cells as Immunotherapy
Published in
Frontiers in immunology, January 2014
DOI 10.3389/fimmu.2014.00046
Pubmed ID
Authors

Benjamin D. Singer, Landon S. King, Franco R. D’Alessio

Abstract

Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed an intense interest in using Tregs for immunotherapy. Conditions that require clinical tolerance to improve outcomes - autoimmune disease, solid organ transplantation, and hematopoietic stem cell transplantation - may benefit from Treg immunotherapy. Investigators have designed ex vivo strategies to isolate, preserve, expand, and infuse Tregs. Protocols to manipulate Treg populations in vivo have also been considered. Barriers to clinically feasible Treg immunotherapy include Treg stability, off-cell effects, and demonstration of cell preparation purity and potency. Clinical trials involving Treg adoptive transfer to treat graft versus host disease preliminarily demonstrated the safety and efficacy of Treg immunotherapy in humans. Future work will need to confirm the safety of Treg immunotherapy and establish the efficacy of specific Treg subsets for the treatment of immune-mediated disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 256 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
France 2 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
United States 1 <1%
Unknown 248 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 60 23%
Student > Ph. D. Student 53 21%
Student > Master 40 16%
Student > Bachelor 25 10%
Other 16 6%
Other 33 13%
Unknown 29 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 67 26%
Medicine and Dentistry 49 19%
Immunology and Microbiology 46 18%
Biochemistry, Genetics and Molecular Biology 20 8%
Chemistry 8 3%
Other 25 10%
Unknown 41 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2023.
All research outputs
#6,611,592
of 26,436,676 outputs
Outputs from Frontiers in immunology
#6,832
of 33,213 outputs
Outputs of similar age
#69,140
of 323,217 outputs
Outputs of similar age from Frontiers in immunology
#13
of 98 outputs
Altmetric has tracked 26,436,676 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 33,213 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,217 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.