Title |
Ontogeny of Myeloid Cells
|
---|---|
Published in |
Frontiers in immunology, September 2014
|
DOI | 10.3389/fimmu.2014.00423 |
Pubmed ID | |
Authors |
Ismé De Kleer, Fabienne Willems, Bart Lambrecht, Stanislas Goriely |
Abstract |
Granulocytes, monocytes, macrophages, and dendritic cells (DCs) represent a subgroup of leukocytes, collectively called myeloid cells. During the embryonic development of mammalians, myelopoiesis occurs in a stepwise fashion that begins in the yolk sac and ends up in the bone marrow (BM). During this process, these early monocyte progenitors colonize various organs such as the brain, liver, skin, and lungs and differentiate into resident macrophages that will self-maintain throughout life. DCs are constantly replenished from BM precursors but can also arise from monocytes in inflammatory conditions. In this review, we summarize the different types of myeloid cells and discuss new insights into their early origin and development in mice and humans from fetal to adult life. We specifically focus on the function of monocytes, macrophages, and DCs at these different developmental stages and on the intrinsic and environmental influences that may drive these adaptations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 3 | <1% |
Germany | 2 | <1% |
Mexico | 1 | <1% |
Unknown | 331 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 74 | 22% |
Researcher | 51 | 15% |
Student > Master | 38 | 11% |
Student > Bachelor | 35 | 10% |
Student > Doctoral Student | 17 | 5% |
Other | 47 | 14% |
Unknown | 75 | 22% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 69 | 20% |
Immunology and Microbiology | 67 | 20% |
Biochemistry, Genetics and Molecular Biology | 55 | 16% |
Medicine and Dentistry | 37 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 2% |
Other | 27 | 8% |
Unknown | 74 | 22% |