Title |
Immunological Relevance of the Coevolution of IDO1 and AHR
|
---|---|
Published in |
Frontiers in immunology, October 2014
|
DOI | 10.3389/fimmu.2014.00521 |
Pubmed ID | |
Authors |
Merja Jaronen, Francisco J. Quintana |
Abstract |
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified because of its role in controlling the cellular response to environmental molecules. More recently, AHR has been shown to play a crucial role in controlling innate and adaptive immune responses through several mechanisms, one of which is the regulation of tryptophan metabolism. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are considered rate-limiting enzymes in the tryptophan catabolism and play important roles in the regulation of the immunity. Moreover, AHR and IDO/TDO are closely interconnected: AHR regulates IDO and TDO expression, and kynurenine produced by IDO/TDO is an AHR agonist. In this review, we propose to examine the relationship between AHR and IDO/TDO and its relevance for the regulation of the immune response in health and disease. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 2 | 2% |
France | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
United States | 1 | <1% |
Unknown | 113 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 29 | 24% |
Student > Ph. D. Student | 24 | 20% |
Student > Master | 13 | 11% |
Other | 9 | 8% |
Student > Doctoral Student | 8 | 7% |
Other | 19 | 16% |
Unknown | 17 | 14% |
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Biochemistry, Genetics and Molecular Biology | 17 | 14% |
Medicine and Dentistry | 14 | 12% |
Immunology and Microbiology | 10 | 8% |
Neuroscience | 6 | 5% |
Other | 16 | 13% |
Unknown | 22 | 18% |