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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Aryl Hydrocarbon Receptor and Kynurenine: Recent Advances in Autoimmune Disease Research
|
|---|---|
| Published in |
Frontiers in immunology, October 2014
|
| DOI | 10.3389/fimmu.2014.00551 |
| Pubmed ID | |
| Authors |
Nam Trung Nguyen, Taisuke Nakahama, Duc Hoang Le, Le Van Son, Ha Hoang Chu, Tadamitsu Kishimoto |
| Abstract |
Aryl hydrocarbon receptor (AHR) is thought to be a crucial factor in the regulation of immune responses. Many AHR-mediated immunoregulatory mechanisms have been discovered, and this knowledge may enhance our understanding of the molecular pathogenesis of autoimmune inflammatory syndromes such as collagen-induced arthritis, experimental autoimmune encephalomyelitis, and experimental colitis. Recent findings have elucidated the critical link between AHR and indoleamine 2,3-dioxygenase (IDO) in the development of regulatory T cells and Th17 cells, which are key factors in a variety of human autoimmune diseases. Induction of IDO and IDO-mediated tryptophan catabolism, together with its downstream products such as kynurenine, is an important immunoregulatory mechanism underlying immunosuppression, tolerance, and immunity. Recent studies revealed that induction of IDO depends on AHR expression. This review summarizes the most current findings regarding the functions of AHR and IDO in immune cells as they relate to the pathogenesis of autoimmune diseases in response to various stimuli. We also discuss the potential link between AHR and IDO/tryptophan metabolites, and the involvement of several novel related factors (such as microRNA) in the development of autoimmune diseases. These novel factors represent potential therapeutic targets for the treatment of autoimmune disorders. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| Canada | 1 | <1% |
| Belgium | 1 | <1% |
| Denmark | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 208 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 41 | 19% |
| Student > Ph. D. Student | 36 | 17% |
| Student > Master | 34 | 16% |
| Other | 20 | 9% |
| Student > Bachelor | 14 | 6% |
| Other | 36 | 17% |
| Unknown | 35 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 26% |
| Medicine and Dentistry | 26 | 12% |
| Biochemistry, Genetics and Molecular Biology | 24 | 11% |
| Immunology and Microbiology | 24 | 11% |
| Chemistry | 10 | 5% |
| Other | 30 | 14% |
| Unknown | 45 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2018.
All research outputs
#16,376,960
of 26,290,088 outputs
Outputs from Frontiers in immunology
#16,049
of 32,925 outputs
Outputs of similar age
#146,763
of 275,122 outputs
Outputs of similar age from Frontiers in immunology
#94
of 186 outputs
Altmetric has tracked 26,290,088 research outputs across all sources so far. This one is in the 36th percentile – i.e., 36% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32,925 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,122 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 186 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.