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The Subtleties and Contrasts of the LeuO Regulator in Salmonella Typhi: Implications in the Immune Response

Overview of attention for article published in Frontiers in immunology, December 2014
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Title
The Subtleties and Contrasts of the LeuO Regulator in Salmonella Typhi: Implications in the Immune Response
Published in
Frontiers in immunology, December 2014
DOI 10.3389/fimmu.2014.00581
Pubmed ID
Authors

Carmen Guadarrama, Tomás Villaseñor, Edmundo Calva

Abstract

Salmonella are facultative intracellular pathogens. Salmonella infection occurs mainly by expression of two Salmonella pathogenicity Islands (SPI-1 and SPI-2). SPI-1 encodes transcriptional factors that participate in the expression of virulence factors encoded in the island. However, there are transcriptional factors encoded outside the island that also participate in the expression of SPI-1-encoded genes. Upon infection, bacteria are capable of avoiding the host immune response with several strategies that involve several virulence factors under the control of transcriptional regulators. Interestingly, LeuO a transcriptional global regulator which is encoded outside of any SPI, is proposed to be part of a complex regulatory network that involves expression of several genes that help bacteria to survive stress conditions and, also, induces the expression of porins that have been shown to be immunogens and can thus be considered as antigenic candidates for acellular vaccines. Hence, the understanding of the LeuO regulon implies a role of bacterial genetic regulation in determining the host immune response.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 23%
Researcher 7 20%
Student > Bachelor 5 14%
Student > Master 3 9%
Student > Postgraduate 2 6%
Other 6 17%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 34%
Biochemistry, Genetics and Molecular Biology 11 31%
Unspecified 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Nursing and Health Professions 1 3%
Other 3 9%
Unknown 5 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2014.
All research outputs
#22,758,309
of 25,373,627 outputs
Outputs from Frontiers in immunology
#27,414
of 31,516 outputs
Outputs of similar age
#310,399
of 363,202 outputs
Outputs of similar age from Frontiers in immunology
#148
of 169 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,516 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.