Cristina Toscano Fonseca, Sergio Costa Oliveira, Clarice Carvalho Alves
Abstract
The successful development of vaccines depends on the knowledge of the immunological mechanisms associated with the elimination of the pathogen. In the case of schistosomes, its complex life cycle and the mechanisms developed to evade host immune system, turns the development of a vaccine against the disease into a very difficult task. Identifying the immunological effector mechanisms involved in parasite attrition and the major targets for its response is a key step to formulate an effective vaccine. Recent studies have described some promising antigens to compose a subunit vaccine and have pointed to some immune factors that play a role in parasite elimination. Here, we review the immune components and effector mechanisms associated with the protective immunity induced by those vaccine candidates and the lessons we have learned from the studies of the acquired resistance to infection in humans. We will also discuss the immune factors that correlate with protection and therefore could help to evaluate those vaccine formulations in clinical trials.
Pharmacology, Toxicology and Pharmaceutical Science
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2%
Other
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11%
Unknown
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29%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2015.
All research outputs
#20,390,694
of 25,932,719 outputs
Outputs from Frontiers in immunology
#23,152
of 32,608 outputs
Outputs of similar age
#191,335
of 275,298 outputs
Outputs of similar age from Frontiers in immunology
#110
of 159 outputs
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We're also able to compare this research output to 159 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
