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Behçet’s Disease: Do Natural Killer Cells Play a Significant Role?

Overview of attention for article published in Frontiers in immunology, March 2015
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Title
Behçet’s Disease: Do Natural Killer Cells Play a Significant Role?
Published in
Frontiers in immunology, March 2015
DOI 10.3389/fimmu.2015.00134
Pubmed ID
Authors

Harry Petrushkin, Samiul Hasan, Miles R. Stanford, Farida Fortune, Graham R. Wallace

Abstract

Behçet's disease (BD) is a complex inflammatory disease, of unknown etiology. While disease pathogenesis remains unclear, a strong relationship between BD and HLA-B*51 has been established over the last 30 years. A number of theories exist regarding the cause of BD; however, few are able to account for the increased rates of HLA-B*51 positive individuals, particularly around the Mediterranean basin and Middle-East where the prevalence is highest. This review outlines current immunogenetic data on BD and the immunoregulatory role natural killer cells may play. It also describes the interaction of the killer immunoglobulin-like receptor - KIR3DL1 with its ligand Bw4, which is found on HLA-B51. Finally, CD94/NKG2D, MICA, and ERAP are outlined with regard to their potential roles in BD.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 14%
Researcher 4 14%
Student > Doctoral Student 3 10%
Other 3 10%
Student > Bachelor 2 7%
Other 6 21%
Unknown 7 24%
Readers by discipline Count As %
Medicine and Dentistry 6 21%
Immunology and Microbiology 6 21%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 3 10%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2015.
All research outputs
#20,653,708
of 25,371,288 outputs
Outputs from Frontiers in immunology
#24,734
of 31,507 outputs
Outputs of similar age
#207,106
of 278,388 outputs
Outputs of similar age from Frontiers in immunology
#115
of 149 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,507 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,388 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 149 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.