Title |
From the Reticuloendothelial to Mononuclear Phagocyte System – The Unaccounted Years
|
---|---|
Published in |
Frontiers in immunology, July 2015
|
DOI | 10.3389/fimmu.2015.00328 |
Pubmed ID | |
Authors |
Simon Yona, Siamon Gordon |
Abstract |
It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review, we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the reticuloendothelial system. Studies on these cells resulted in a substantial literature spanning immunology, hematology, biochemistry, and pathology. Early histological studies on morphology and in situ labeling laid the foundations to appreciate the diversity and functional capacity of these cells in the steady state and during pathology. We complete this phagocyte retrospective with the establishment of the mononuclear phagocyte system nomenclature half a century ago. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 27% |
United States | 2 | 18% |
Spain | 2 | 18% |
Curaçao | 1 | 9% |
Switzerland | 1 | 9% |
Unknown | 2 | 18% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 45% |
Scientists | 3 | 27% |
Science communicators (journalists, bloggers, editors) | 2 | 18% |
Practitioners (doctors, other healthcare professionals) | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 171 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 22% |
Student > Bachelor | 24 | 14% |
Student > Master | 23 | 13% |
Researcher | 16 | 9% |
Student > Postgraduate | 7 | 4% |
Other | 16 | 9% |
Unknown | 47 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 25 | 15% |
Medicine and Dentistry | 25 | 15% |
Immunology and Microbiology | 24 | 14% |
Agricultural and Biological Sciences | 15 | 9% |
Chemistry | 9 | 5% |
Other | 20 | 12% |
Unknown | 53 | 31% |