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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Role of Dipeptidyl Peptidase – 4 Inhibitors in Diabetic Kidney Disease
|
|---|---|
| Published in |
Frontiers in immunology, August 2015
|
| DOI | 10.3389/fimmu.2015.00443 |
| Pubmed ID | |
| Authors |
Usha Panchapakesan, Carol Pollock |
| Abstract |
Despite major advances in the understanding of the molecular mechanisms that underpin the development of diabetic kidney disease, current best practice still leaves a significant proportion of patients with end-stage kidney disease requiring renal replacement therapy. This is on a background of an increasing diabetes epidemic worldwide. Although kidney failure is a major cause of morbidity the main cause of death remains cardiovascular in nature. Hence, diabetic therapies which are both "cardio-renal" protective seem the logical way forward. In this review, we discuss the dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4inh), which are glucose-lowering agents used clinically and their role in diabetic kidney disease with specific focus on renoprotection and surrogate markers of cardiovascular disease. We highlight the novel pleiotropic effects of DPP4 that make it an attractive additional target to combat the fibrotic and inflammatory pathways in diabetic kidney disease and also discuss the current literature on the cardiovascular safety profile of DPP4inh. Clearly, these observed renoprotective effects will need to be confirmed by clinical trials to determine whether they translate into beneficial effects to patients with diabetes. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 2% |
| Unknown | 40 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 12% |
| Researcher | 5 | 12% |
| Student > Ph. D. Student | 4 | 10% |
| Student > Postgraduate | 3 | 7% |
| Other | 3 | 7% |
| Other | 6 | 15% |
| Unknown | 15 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 12% |
| Agricultural and Biological Sciences | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Unspecified | 1 | 2% |
| Other | 4 | 10% |
| Unknown | 15 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2015.
All research outputs
#20,674,485
of 25,394,764 outputs
Outputs from Frontiers in immunology
#24,770
of 31,554 outputs
Outputs of similar age
#205,432
of 279,702 outputs
Outputs of similar age from Frontiers in immunology
#124
of 159 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,554 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
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We're also able to compare this research output to 159 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.