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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Activating KIRs and NKG2C in Viral Infections: Toward NK Cell Memory?
|
|---|---|
| Published in |
Frontiers in immunology, November 2015
|
| DOI | 10.3389/fimmu.2015.00573 |
| Pubmed ID | |
| Authors |
Mariella Della Chiesa, Simona Sivori, Simona Carlomagno, Lorenzo Moretta, Alessandro Moretta |
| Abstract |
Natural killer (NK) cells are important players in the immune defense against viral infections. The contribution of activating killer immunoglobulin-like receptors (KIRs) and CD94/NKG2C in regulating anti-viral responses has recently emerged. Thus, in the hematopoietic stem cell transplantation setting, the presence of donor activating KIRs (aKIRs) may protect against viral infections, while in HIV-infected individuals, KIR3DS1, in combination with HLA-Bw4-I80, results in reduction of viral progression. Since, studies have been performed mainly at the genetic or transcriptional level, the effective size, the function, and the "licensing" status of NK cells expressing aKIRs, as well as the nature of their viral ligands, require further investigation. Certain viral infections, mainly due to Human cytomegalovirus (HCMV), can deeply influence the NK cell development and function by inducing a marked expansion of mature NKG2C(+) NK cells expressing self-activating KIRs. This suggests that NKG2C and/or aKIRs are involved in the selective proliferation of this subset. The persistent, HCMV-induced, imprinting suggests that NK cells may display unexpected adaptive immune traits. The role of aKIRs and NKG2C in regulating NK cell responses and promoting a memory-like response to certain viruses is discussed. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 98 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 21% |
| Researcher | 16 | 16% |
| Student > Master | 12 | 12% |
| Student > Bachelor | 10 | 10% |
| Other | 10 | 10% |
| Other | 14 | 14% |
| Unknown | 17 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 32 | 32% |
| Agricultural and Biological Sciences | 17 | 17% |
| Biochemistry, Genetics and Molecular Biology | 15 | 15% |
| Medicine and Dentistry | 13 | 13% |
| Computer Science | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 19 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2015.
All research outputs
#16,423,440
of 25,932,719 outputs
Outputs from Frontiers in immunology
#17,146
of 32,608 outputs
Outputs of similar age
#159,672
of 298,556 outputs
Outputs of similar age from Frontiers in immunology
#84
of 151 outputs
Altmetric has tracked 25,932,719 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32,608 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,556 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 151 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.