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Translating Treg Therapy in Humanized Mice

Overview of attention for article published in Frontiers in immunology, December 2015
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3 X users

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60 Mendeley
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Title
Translating Treg Therapy in Humanized Mice
Published in
Frontiers in immunology, December 2015
DOI 10.3389/fimmu.2015.00623
Pubmed ID
Authors

Susanne A. Hahn, Iris Bellinghausen, Bettina Trinschek, Christian Becker

Abstract

Regulatory T cells (Treg) control immune cell function as well as non-immunological processes. Their far-reaching regulatory activities suggest their functional manipulation as a means to sustainably and causally intervene with the course of diseases. Preclinical tools and strategies are however needed to further test and develop interventional strategies outside the human body. "Humanized" mouse models consisting of mice engrafted with human immune cells and tissues provide new tools to analyze human Treg ontogeny, immunobiology, and therapy. Here, we summarize the current state of humanized mouse models as a means to study human Treg function at the molecular level and to design strategies to harness these cells for therapeutic purposes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 32%
Student > Ph. D. Student 11 18%
Other 6 10%
Professor > Associate Professor 4 7%
Student > Bachelor 4 7%
Other 7 12%
Unknown 9 15%
Readers by discipline Count As %
Immunology and Microbiology 18 30%
Biochemistry, Genetics and Molecular Biology 10 17%
Agricultural and Biological Sciences 8 13%
Medicine and Dentistry 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 5 8%
Unknown 11 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2015.
All research outputs
#16,784,715
of 25,461,852 outputs
Outputs from Frontiers in immunology
#18,424
of 31,698 outputs
Outputs of similar age
#229,459
of 396,697 outputs
Outputs of similar age from Frontiers in immunology
#80
of 131 outputs
Altmetric has tracked 25,461,852 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,698 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,697 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.