Title |
Immunological Landscape and Clinical Management of Rectal Cancer
|
---|---|
Published in |
Frontiers in immunology, February 2016
|
DOI | 10.3389/fimmu.2016.00061 |
Pubmed ID | |
Authors |
Elísabeth Pérez-Ruiz, Pedro Berraondo |
Abstract |
The clinical management of rectal cancer and colon cancer differs due to increased local relapses in rectal cancer. However, the current molecular classification does not differentiate rectal cancer and colon cancer as two different entities. In recent years, the impact of the specific immune microenvironment in cancer has attracted renewed interest and is currently recognized as one of the major determinants of clinical progression in a wide range of tumors. In colorectal cancer, the density of lymphocytic infiltration is associated with better overall survival. Due to the need for biomarkers of response to conventional treatment with chemoradiotherapy in rectal tumors, the immune status of rectal cancer emerges as a useful tool to improve the management of patients. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 8 | 27% |
Student > Ph. D. Student | 7 | 23% |
Student > Master | 3 | 10% |
Student > Postgraduate | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
Other | 4 | 13% |
Unknown | 4 | 13% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 37% |
Agricultural and Biological Sciences | 5 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Immunology and Microbiology | 2 | 7% |
Computer Science | 1 | 3% |
Other | 3 | 10% |
Unknown | 5 | 17% |