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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Allosteric Modulation of Chemoattractant Receptors
|
|---|---|
| Published in |
Frontiers in immunology, May 2016
|
| DOI | 10.3389/fimmu.2016.00170 |
| Pubmed ID | |
| Authors |
Marcello Allegretti, Maria Candida Cesta, Massimo Locati |
| Abstract |
Chemoattractants control selective leukocyte homing via interactions with a dedicated family of related G protein-coupled receptor (GPCR). Emerging evidence indicates that the signaling activity of these receptors, as for other GPCR, is influenced by allosteric modulators, which interact with the receptor in a binding site distinct from the binding site of the agonist and modulate the receptor signaling activity in response to the orthosteric ligand. Allosteric modulators have a number of potential advantages over orthosteric agonists/antagonists as therapeutic agents and offer unprecedented opportunities to identify extremely selective drug leads. Here, we resume evidence of allosterism in the context of chemoattractant receptors, discussing in particular its functional impact on functional selectivity and probe/concentration dependence of orthosteric ligands activities. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 47 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 23% |
| Researcher | 8 | 17% |
| Student > Ph. D. Student | 7 | 15% |
| Student > Master | 6 | 13% |
| Student > Doctoral Student | 4 | 9% |
| Other | 4 | 9% |
| Unknown | 7 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 13 | 28% |
| Biochemistry, Genetics and Molecular Biology | 8 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 11% |
| Agricultural and Biological Sciences | 4 | 9% |
| Medicine and Dentistry | 2 | 4% |
| Other | 6 | 13% |
| Unknown | 9 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2016.
All research outputs
#20,591,478
of 26,179,695 outputs
Outputs from Frontiers in immunology
#23,321
of 33,036 outputs
Outputs of similar age
#220,156
of 314,170 outputs
Outputs of similar age from Frontiers in immunology
#100
of 136 outputs
Altmetric has tracked 26,179,695 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 33,036 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,170 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.