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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Toll-Like Receptor 2 Mediates In Vivo Pro- and Anti-inflammatory Effects of Mycobacterium Tuberculosis and Modulates Autoimmune Encephalomyelitis
|
|---|---|
| Published in |
Frontiers in immunology, May 2016
|
| DOI | 10.3389/fimmu.2016.00191 |
| Pubmed ID | |
| Authors |
Alessia Piermattei, Giuseppe Migliara, Gabriele Di Sante, Maria Foti, Soren Bohos Hayrabedyan, Angela Papagna, Maria Concetta Geloso, Maddalena Corbi, Mariagrazia Valentini, Alessandro Sgambato, Giovanni Delogu, Gabriela Constantin, Francesco Ria |
| Abstract |
Mycobacteria display pro- and anti-inflammatory effects in human and experimental pathology. We show here that both effects are mediated by Toll-like receptor 2 (Tlr2), by exploiting a previously characterized Tlr2 variant (Met82Ile). Tlr2 82ile promoted self-specific proinflammatory polarization as well as expansion of ag-specific FoxP3(+) Tregs, while Tlr2 82met impairs the expansion of Tregs and reduces the production of IFN-γ and IL-17 proinflammatory cytokines. Preferential dimerization with Tlr1 or Tlr6 could not explain these differences. In silico, we showed that Tlr2 variant Met82Ile modified the binding pocket for peptidoglycans and participated directly to a putative binding pocket for sugars and cadherins. The distinct pro- and anti-inflammatory actions impacted severity, extent of remission, and distribution of the lesions within the central nervous system of experimental autoimmune encephalomyelitis. Thus, Tlr2 has a janus function in vivo as mediator of the role of bacterial products in balancing pro- and anti-inflammatory immune responses. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 26% |
| Student > Bachelor | 6 | 15% |
| Student > Doctoral Student | 4 | 10% |
| Professor | 4 | 10% |
| Professor > Associate Professor | 3 | 8% |
| Other | 6 | 15% |
| Unknown | 6 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 8 | 21% |
| Agricultural and Biological Sciences | 5 | 13% |
| Neuroscience | 4 | 10% |
| Medicine and Dentistry | 4 | 10% |
| Biochemistry, Genetics and Molecular Biology | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 8 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2016.
All research outputs
#17,258,644
of 26,311,549 outputs
Outputs from Frontiers in immunology
#18,919
of 32,936 outputs
Outputs of similar age
#213,456
of 351,572 outputs
Outputs of similar age from Frontiers in immunology
#87
of 136 outputs
Altmetric has tracked 26,311,549 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 32,936 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 351,572 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 136 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.