Title |
Transfusion as an Inflammation Hit: Knowns and Unknowns
|
---|---|
Published in |
Frontiers in immunology, November 2016
|
DOI | 10.3389/fimmu.2016.00534 |
Pubmed ID | |
Authors |
Olivier Garraud, S. Tariket, C. Sut, A. Haddad, C. Aloui, T. Chakroun, S. Laradi, F. Cognasse |
Abstract |
Transfusion of blood cell components is frequent in the therapeutic arsenal; it is globally safe or even very safe. At present, residual clinical manifestations are principally inflammatory in nature. If some rare clinical hazards manifest as acute inflammation symptoms of various origin, most of them linked with conflicting and undesirable biological material accompanying the therapeutic component (infectious pathogen, pathogenic antibody, unwanted antigen, or allergen), the general feature is subtler and less visible, and essentially consists of alloimmunization or febrile non-hemolytic transfusion reaction. The present essay aims to present updates in hematology and immunology that help understand how, when, and why subclinical inflammation underlies alloimmunization and circumstances characteristic of red blood cells and - even more frequently - platelets that contribute inflammatory mediators. Modern transfusion medicine makes sustained efforts to limit such inflammatory hazards; efforts can be successful only if one has a clear view of each element's role. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Mexico | 2 | 29% |
Brazil | 1 | 14% |
Switzerland | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 67 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 19% |
Other | 9 | 13% |
Student > Postgraduate | 7 | 10% |
Student > Bachelor | 6 | 9% |
Student > Ph. D. Student | 5 | 7% |
Other | 12 | 18% |
Unknown | 15 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 37% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Agricultural and Biological Sciences | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Nursing and Health Professions | 3 | 4% |
Other | 7 | 10% |
Unknown | 19 | 28% |