Catharina C. Gross, Andreas Schulte-Mecklenbeck, Heinz Wiendl, Emanuela Marcenaro, Nicole Kerlero de Rosbo, Antonio Uccelli, Alice Laroni
Abstract
There is increasing evidence that natural killer (NK) cells exhibit regulatory features. Among them, CD56(bright) NK cells have been suggested to play a major role in controlling T cell responses and maintaining homeostasis. Dysfunction in NK cell-mediated regulatory features has been recently described in untreated multiple sclerosis (MS), suggesting a contribution to MS pathogenesis. Moreover, biological disease-modifying treatments effective in MS apparently enhance the frequencies and/or regulatory function of NK cells, further pointing toward an immunoprotective role of NK cells in MS. Here, we summarize the current knowledge on the regulatory functions of NK cells, based on their interactions with other cells belonging to the innate compartment, as well as with adaptive effector cells. We review the more recent data reporting disruption of NK cell/T cell interactions in MS and discuss how disease-modifying treatments for MS affect NK cells.
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2016.
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#6,551,915
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#6,875
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#108,873
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Outputs of similar age from Frontiers in immunology
#68
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Altmetric has tracked 25,703,943 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 32,216 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done well, scoring higher than 78% of its peers.
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We're also able to compare this research output to 286 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.
