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Bidirectional Crosstalk between Lymphatic Endothelial Cell and T Cell and Its Implications in Tumor Immunity

Overview of attention for article published in Frontiers in immunology, February 2017
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  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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Title
Bidirectional Crosstalk between Lymphatic Endothelial Cell and T Cell and Its Implications in Tumor Immunity
Published in
Frontiers in immunology, February 2017
DOI 10.3389/fimmu.2017.00083
Pubmed ID
Authors

Kim Pin Yeo, Veronique Angeli

Abstract

Lymphatic vessels have been traditionally considered as passive transporters of fluid and lipids. However, it is apparent from recent literature that the function of lymphatic vessels is not only restricted to fluid balance homeostasis but also extends to regulation of immune cell trafficking, antigen presentation, tolerance, and immunity, all which may impact the progression of inflammatory responses and diseases such as cancer. The lymphatic system and the immune system are intimately connected, and there is emergent evidence for a crosstalk between T cell and lymphatic endothelial cell (LEC). This review describes how LECs in lymph nodes can affect multiple functional properties of T cells and the impact of these LEC-driven effects on adaptive immunity and, conversely, how T cells can modulate LEC growth. The significance of such crosstalk between T cells and LECs in cancer will also be discussed.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 26%
Researcher 13 20%
Student > Master 9 14%
Student > Doctoral Student 5 8%
Student > Bachelor 4 6%
Other 6 9%
Unknown 12 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 24%
Agricultural and Biological Sciences 11 17%
Immunology and Microbiology 10 15%
Medicine and Dentistry 7 11%
Engineering 5 8%
Other 5 8%
Unknown 12 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2017.
All research outputs
#14,539,224
of 25,382,440 outputs
Outputs from Frontiers in immunology
#12,123
of 31,531 outputs
Outputs of similar age
#212,881
of 424,791 outputs
Outputs of similar age from Frontiers in immunology
#179
of 391 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,791 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 391 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.