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The Immunoregulatory Potential of Particle Radiation in Cancer Therapy

Overview of attention for article published in Frontiers in immunology, February 2017
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Title
The Immunoregulatory Potential of Particle Radiation in Cancer Therapy
Published in
Frontiers in immunology, February 2017
DOI 10.3389/fimmu.2017.00099
Pubmed ID
Authors

Daniel K. Ebner, Walter Tinganelli, Alexander Helm, Alessandra Bisio, Shigeru Yamada, Tadashi Kamada, Takashi Shimokawa, Marco Durante

Abstract

Cancer treatment, today, consists of surgery, chemotherapy, radiation, and most recently immunotherapy. Combination immunotherapy-radiotherapy (CIR) has experienced a surge in public attention due to numerous clinical publications outlining the reduction or elimination of metastatic disease, following treatment with specifically ipilimumab and radiotherapy. The mechanism behind CIR, however, remains unclear, though it is hypothesized that radiation transforms the tumor into an in situ vaccine which immunotherapy modulates into a larger immune response. To date, the majority of attention has focused on rotating out immunotherapeutics with conventional radiation; however, the unique biological and physical benefits of particle irradiation may prove superior in generation of systemic effect. Here, we review recent advances in CIR, with a particular focus on the usage of charged particles to induce or enhance response to cancerous disease.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 78 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 19%
Researcher 12 15%
Student > Master 12 15%
Other 8 10%
Student > Bachelor 4 5%
Other 13 17%
Unknown 14 18%
Readers by discipline Count As %
Medicine and Dentistry 18 23%
Physics and Astronomy 10 13%
Biochemistry, Genetics and Molecular Biology 9 12%
Agricultural and Biological Sciences 7 9%
Computer Science 2 3%
Other 7 9%
Unknown 25 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 February 2017.
All research outputs
#20,903,356
of 26,557,909 outputs
Outputs from Frontiers in immunology
#23,784
of 33,377 outputs
Outputs of similar age
#314,235
of 431,647 outputs
Outputs of similar age from Frontiers in immunology
#300
of 391 outputs
Altmetric has tracked 26,557,909 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 33,377 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,647 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 391 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.