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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment
|
|---|---|
| Published in |
Frontiers in immunology, March 2017
|
| DOI | 10.3389/fimmu.2017.00270 |
| Pubmed ID | |
| Authors |
Soumaya Kouidhi, Amel Benammar Elgaaied, Salem Chouaib |
| Abstract |
The immune system and metabolism are highly integrated and multilevel interactions between metabolic system and T lymphocyte signaling and fate exist. Accumulating evidence indicates that the regulation of nutrient uptake and utilization in T cells is critically important for the control of their differentiation and manipulating metabolic pathways in these cells can shape their function and survival. This review will discuss some potential cell metabolism pathways involved in shaping T lymphocyte function and differentiation. It will also describe show subsets of T cells have specific metabolic requirements and signaling pathways that contribute to their respective function. Examples showing the apparent similarity between cancer cell metabolism and T cells during activation are illustrated and finally some mechanisms being used by tumor microenvironment to orchestrate T-cell metabolic dysregulation and the subsequent emergence of immune suppression are discussed. We believe that targeting T-cell metabolism may provide an additional opportunity to manipulate T-cell function in the development of novel therapeutics. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 26% |
| Germany | 2 | 11% |
| United Kingdom | 1 | 5% |
| Taiwan | 1 | 5% |
| Unknown | 10 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 74% |
| Scientists | 4 | 21% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 190 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 22% |
| Researcher | 33 | 17% |
| Student > Master | 20 | 11% |
| Student > Doctoral Student | 16 | 8% |
| Student > Bachelor | 14 | 7% |
| Other | 25 | 13% |
| Unknown | 40 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 51 | 27% |
| Immunology and Microbiology | 48 | 25% |
| Agricultural and Biological Sciences | 15 | 8% |
| Medicine and Dentistry | 14 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 14 | 7% |
| Unknown | 44 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2020.
All research outputs
#2,576,363
of 25,411,814 outputs
Outputs from Frontiers in immunology
#2,578
of 31,614 outputs
Outputs of similar age
#47,234
of 322,526 outputs
Outputs of similar age from Frontiers in immunology
#42
of 446 outputs
Altmetric has tracked 25,411,814 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,614 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,526 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 446 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.