Title |
Antifungal Immunological Defenses in Newborns
|
---|---|
Published in |
Frontiers in immunology, March 2017
|
DOI | 10.3389/fimmu.2017.00281 |
Pubmed ID | |
Authors |
Christina Michalski, Bernard Kan, Pascal M. Lavoie |
Abstract |
Newborns are prone to fungal infections, largely due to Candida species. The immunological basis for this vulnerability is not yet fully understood. However, useful insights can be gained from the knowledge of the maturation of immune pathways during ontogeny, particularly when placed in context with how rare genetic mutations in humans predispose to fungal diseases. In this article, we review these most current data on immune functions in human newborns, highlighting pathways most relevant to the response to Candida. While discussing these data, we propose a framework of why deficiencies in these pathways make newborns particularly vulnerable to this opportunistic pathogen. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 22% |
United Kingdom | 1 | 11% |
Brazil | 1 | 11% |
Unknown | 5 | 56% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 5 | 56% |
Scientists | 3 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 6 | 18% |
Student > Master | 5 | 15% |
Student > Bachelor | 4 | 12% |
Student > Ph. D. Student | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Other | 5 | 15% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 27% |
Agricultural and Biological Sciences | 4 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Immunology and Microbiology | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Other | 4 | 12% |
Unknown | 8 | 24% |