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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice
|
|---|---|
| Published in |
Frontiers in immunology, March 2017
|
| DOI | 10.3389/fimmu.2017.00291 |
| Pubmed ID | |
| Authors |
Priya D. A. Issuree, Charles P. Ng, Dan R. Littman |
| Abstract |
The adaptive immune system is dependent on functionally distinct lineages of T cell antigen receptor αβ-expressing T cells that differentiate from a common progenitor in the thymus. CD4(+)CD8(+) progenitor thymocytes undergo selection following interaction with MHC class I and class II molecules bearing peptide self-antigens, giving rise to CD8(+) cytotoxic and CD4(+) helper or regulatory T cell lineages, respectively. The strict correspondence of CD4 and CD8 expression with distinct cellular phenotypes has made their genes useful surrogates for investigating molecular mechanisms of lineage commitment. Studies of Cd4 and Cd8 transcriptional regulation have uncovered cis-regulatory elements that are critical for mediating epigenetic modifications at distinct stages of development to establish heritable transcriptional programs. In this review, we examine the epigenetic mechanisms involved in Cd4 and Cd8 gene regulation during T cell lineage specification and highlight the features that make this an attractive system for uncovering molecular mechanisms of heritability. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 40% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 35 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 28% |
| Researcher | 10 | 28% |
| Student > Master | 4 | 11% |
| Student > Bachelor | 3 | 8% |
| Student > Doctoral Student | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 47% |
| Immunology and Microbiology | 9 | 25% |
| Agricultural and Biological Sciences | 4 | 11% |
| Medicine and Dentistry | 1 | 3% |
| Unknown | 5 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2017.
All research outputs
#14,787,133
of 25,382,440 outputs
Outputs from Frontiers in immunology
#12,926
of 31,531 outputs
Outputs of similar age
#164,078
of 322,842 outputs
Outputs of similar age from Frontiers in immunology
#251
of 441 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,842 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 441 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.