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X Demographics
Mendeley readers
Attention Score in Context
| Title |
RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?
|
|---|---|
| Published in |
Frontiers in immunology, March 2017
|
| DOI | 10.3389/fimmu.2017.00331 |
| Pubmed ID | |
| Authors |
Zhongji Meng, Mengji Lu |
| Abstract |
RNA interference (RNAi) is a natural cellular mechanism that inhibits gene expression in a sequence-specific manner. In the last decade, RNAi has become a cornerstone in basic biological systems research and drug development efforts. The RNAi-based manipulation of mammalian cells facilitates target identification and validation; assists in identifying human disease etiologies; and expedites the development of treatments for infectious diseases, cancer, and other conditions. Several RNAi-based approaches are currently undergoing assessment in phase I and II clinical trials. However, RNAi-associated immune stimulation might act as a hurdle to safe and effective RNAi, particularly in clinical applications. The induction of innate immunity may originate from small interfering RNA (siRNA) sequence-dependent delivery vehicles and even the RNAi process itself. However, in the case of antagonistic cancers and viral infection, immune activation is beneficial; thus, immunostimulatory small interfering RNAs were designed to create bifunctional small molecules with RNAi and immunostimulatory activities. This review summarizes the research studies of RNAi-associated immune stimulation and the approaches for manipulating immunostimulatory activities. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 22% |
| Spain | 1 | 11% |
| Germany | 1 | 11% |
| Mexico | 1 | 11% |
| Venezuela, Bolivarian Republic of | 1 | 11% |
| Switzerland | 1 | 11% |
| Unknown | 2 | 22% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 3 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 190 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 17% |
| Student > Bachelor | 31 | 16% |
| Researcher | 30 | 16% |
| Student > Master | 18 | 9% |
| Student > Doctoral Student | 6 | 3% |
| Other | 14 | 7% |
| Unknown | 58 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 45 | 24% |
| Agricultural and Biological Sciences | 26 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 7% |
| Medicine and Dentistry | 11 | 6% |
| Chemistry | 8 | 4% |
| Other | 22 | 12% |
| Unknown | 64 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2022.
All research outputs
#6,573,525
of 25,382,440 outputs
Outputs from Frontiers in immunology
#6,986
of 31,531 outputs
Outputs of similar age
#97,979
of 322,668 outputs
Outputs of similar age from Frontiers in immunology
#125
of 441 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 322,668 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 441 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.