Luca Pangrazzi, Erin Naismith, Andreas Meryk, Michael Keller, Brigitte Jenewein, Klemens Trieb, Beatrix Grubeck-Loebenstein
Abstract
Cytomegalovirus (CMV) has been described as a contributor to immunosenescence, thus exacerbating age-related diseases. In persons with latent CMV infection, the CD8(+) T cell compartment is irreversibly changed, leading to the accumulation of highly differentiated virus-specific CD8(+) T cells in the peripheral blood. The bone marrow (BM) has been shown to play a major role in the long-term survival of antigen-experienced T cells. Effector CD8(+) T cells are preferentially maintained by the cytokine IL-15, the expression of which increases in old age. However, the impact of CMV on the phenotype of effector CD8(+) T cells and on the production of T cell survival molecules in the BM is not yet known. We now show, using BM samples obtained from persons who underwent hip replacement surgery because of osteoarthrosis, that senescent CD8(+) TEMRA cells with a bright expression of CD45RA and a high responsiveness to IL-15 accumulate in the BM of CMV-infected persons. A negative correlation was found between CMV antibody (Ab) titers in the serum and the expression of CD28 and IL-7Rα in CD8(+) [Formula: see text] cells. Increased IL-15 mRNA levels were observed in the BM of CMV(+) compared to CMV(-) persons, being particularly high in old seropositive individuals. In summary, our results indicate that a BM environment rich in IL-15 may play an important role in the maintenance of highly differentiated CD8(+) T cells generated after CMV infection.
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2022.
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#6,681,599
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#7,139
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Outputs of similar age from Frontiers in immunology
#113
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Altmetric has tracked 25,703,943 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 32,216 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has done well, scoring higher than 77% of its peers.
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