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X Demographics
Mendeley readers
Attention Score in Context
| Title |
β-Glucan Size Controls Dectin-1-Mediated Immune Responses in Human Dendritic Cells by Regulating IL-1β Production
|
|---|---|
| Published in |
Frontiers in immunology, July 2017
|
| DOI | 10.3389/fimmu.2017.00791 |
| Pubmed ID | |
| Authors |
Matthew J. Elder, Steve J. Webster, Ronnie Chee, David L. Williams, J. S. Hill Gaston, Jane C. Goodall |
| Abstract |
Dectin-1/CLEC7A is a pattern recognition receptor that recognizes β-1,3 glucans, and its stimulation initiates signaling events characterized by the production of inflammatory cytokines from human dendritic cells (DCs) required for antifungal immunity. β-glucans differ greatly in size, structure, and ability to activate effector immune responses from DC; as such, small particulate β-glucans are thought to be poor activators of innate immunity. We show that β-glucan particle size is a critical factor contributing to the secretion of cytokines from human DC; large β-glucan-stimulated DC generate significantly more IL-1β, IL-6, and IL-23 compared to those stimulated with the smaller β-glucans. In marked contrast, the secretion of TSLP and CCL22 were found to be insensitive to β-glucan particle size. Furthermore, we show that the capacity to induce phagocytosis, and the relative IL-1β production determined by β-glucan size, regulates the composition of the cytokine milieu generated from DC. This suggests that β-glucan particle size is critically important in orchestrating the nature of the immune response to fungi. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 14% |
| Unknown | 6 | 86% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 57% |
| Practitioners (doctors, other healthcare professionals) | 1 | 14% |
| Scientists | 1 | 14% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 20% |
| Researcher | 14 | 18% |
| Student > Bachelor | 9 | 11% |
| Student > Master | 5 | 6% |
| Student > Doctoral Student | 4 | 5% |
| Other | 7 | 9% |
| Unknown | 24 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 16 | 20% |
| Agricultural and Biological Sciences | 14 | 18% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Chemistry | 5 | 6% |
| Medicine and Dentistry | 3 | 4% |
| Other | 8 | 10% |
| Unknown | 23 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 October 2021.
All research outputs
#8,136,524
of 26,311,549 outputs
Outputs from Frontiers in immunology
#9,597
of 32,936 outputs
Outputs of similar age
#115,253
of 331,009 outputs
Outputs of similar age from Frontiers in immunology
#150
of 417 outputs
Altmetric has tracked 26,311,549 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 32,936 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,009 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 417 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.