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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of Dendritic Cells in Inflammation and Loss of Tolerance in the Elderly
|
|---|---|
| Published in |
Frontiers in immunology, July 2017
|
| DOI | 10.3389/fimmu.2017.00896 |
| Pubmed ID | |
| Authors |
Anshu Agrawal, Sudhanshu Agrawal, Sudhir Gupta |
| Abstract |
Dendritic cells (DCs) play an important role in advancing age-associated progressive decline in adaptive immune responses, loss of tolerance, and development of chronic inflammation. In aged humans, DCs secrete increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory and immune-regulatory cytokines. This may contribute to both chronic inflammation and loss of tolerance in aging. Aged DCs also display increased immune response against self-antigens contributing further to both inflammation and loss of tolerance. The secretion of innate protective cytokines such as type I and III interferons is decreased, and the function of DCs in airway remodeling and inflammation in aged is also compromised. Furthermore, the capacity of DCs to prime T cell responses also seems to be affected. Collectively, these changes in DC functions contribute to the immune dysfunction and inflammation in the elderly. This review only focuses on age-associated changes in DC function in humans. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 2 | 20% |
| United States | 2 | 20% |
| Spain | 2 | 20% |
| Switzerland | 1 | 10% |
| United Kingdom | 1 | 10% |
| Unknown | 2 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 60% |
| Scientists | 3 | 30% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 15% |
| Student > Ph. D. Student | 18 | 14% |
| Student > Bachelor | 13 | 10% |
| Student > Postgraduate | 8 | 6% |
| Student > Master | 7 | 6% |
| Other | 16 | 13% |
| Unknown | 46 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 21 | 17% |
| Medicine and Dentistry | 16 | 13% |
| Biochemistry, Genetics and Molecular Biology | 16 | 13% |
| Agricultural and Biological Sciences | 9 | 7% |
| Engineering | 4 | 3% |
| Other | 10 | 8% |
| Unknown | 51 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2017.
All research outputs
#6,713,860
of 25,806,080 outputs
Outputs from Frontiers in immunology
#7,189
of 32,415 outputs
Outputs of similar age
#96,332
of 328,149 outputs
Outputs of similar age from Frontiers in immunology
#105
of 423 outputs
Altmetric has tracked 25,806,080 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 32,415 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,149 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 423 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.