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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Developmental and Functional Control of Natural Killer Cells by Cytokines
|
|---|---|
| Published in |
Frontiers in immunology, August 2017
|
| DOI | 10.3389/fimmu.2017.00930 |
| Pubmed ID | |
| Authors |
Yang Wu, Zhigang Tian, Haiming Wei |
| Abstract |
Natural killer (NK) cells are effective in combating infections and tumors and as such are tempting for adoptive transfer therapy. However, they are not homogeneous but can be divided into three main subsets, including cytotoxic, tolerant, and regulatory NK cells, with disparate phenotypes and functions in diverse tissues. The development and functions of such NK cells are controlled by various cytokines, such as fms-like tyrosine kinase 3 ligand (FL), kit ligand (KL), interleukin (IL)-3, IL-10, IL-12, IL-18, transforming growth factor-β, and common-γ chain family cytokines, which operate at different stages by regulating distinct signaling pathways. Nevertheless, the specific roles of each cytokine that regulates NK cell development or that shapes different NK cell functions remain unclear. In this review, we attempt to describe the characteristics of each cytokine and the existing protocols to expand NK cells using different combinations of cytokines and feeder cells. A comprehensive understanding of the role of cytokines in NK cell development and function will aid the generation of better efficacy for adoptive NK cell treatment. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 370 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 370 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 70 | 19% |
| Researcher | 50 | 14% |
| Student > Master | 49 | 13% |
| Student > Bachelor | 46 | 12% |
| Student > Doctoral Student | 21 | 6% |
| Other | 32 | 9% |
| Unknown | 102 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 85 | 23% |
| Biochemistry, Genetics and Molecular Biology | 79 | 21% |
| Medicine and Dentistry | 34 | 9% |
| Agricultural and Biological Sciences | 31 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 2% |
| Other | 27 | 7% |
| Unknown | 107 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 January 2023.
All research outputs
#4,761,537
of 25,382,440 outputs
Outputs from Frontiers in immunology
#5,193
of 31,531 outputs
Outputs of similar age
#77,311
of 327,293 outputs
Outputs of similar age from Frontiers in immunology
#74
of 424 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 31,531 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,293 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 424 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.