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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy
|
|---|---|
| Published in |
Frontiers in immunology, September 2017
|
| DOI | 10.3389/fimmu.2017.01124 |
| Pubmed ID | |
| Authors |
Sourav Paul, Girdhari Lal |
| Abstract |
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a broad array of tissue distribution and phenotypic variability. NK cells express several activating and inhibitory receptors that recognize the altered expression of proteins on target cells and control the cytolytic function. NK cells have been used in several clinical trials to control tumor growth. However, the results are encouraging only in hematological malignancies but not very promising in solid tumors. Increasing evidence suggests that tumor microenvironment regulate the phenotype and function of NK cells. In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on effector and cytolytic function of NK cells. We also summarized various NK cell-based immunotherapeutic strategies used in the past and the possibilities to improve the function of NK cell for the better clinical outcome. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 1 | 9% |
| United States | 1 | 9% |
| Unknown | 9 | 82% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 64% |
| Scientists | 2 | 18% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 1,209 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1209 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 178 | 15% |
| Student > Ph. D. Student | 174 | 14% |
| Student > Master | 147 | 12% |
| Researcher | 93 | 8% |
| Student > Doctoral Student | 57 | 5% |
| Other | 86 | 7% |
| Unknown | 474 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 230 | 19% |
| Immunology and Microbiology | 169 | 14% |
| Agricultural and Biological Sciences | 93 | 8% |
| Medicine and Dentistry | 84 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 33 | 3% |
| Other | 110 | 9% |
| Unknown | 490 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 36. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2024.
All research outputs
#1,179,208
of 26,398,142 outputs
Outputs from Frontiers in immunology
#1,050
of 33,126 outputs
Outputs of similar age
#22,698
of 328,395 outputs
Outputs of similar age from Frontiers in immunology
#15
of 491 outputs
Altmetric has tracked 26,398,142 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,126 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,395 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 491 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.