Title |
Activation of Toll Pathway Is Different between Kuruma Shrimp and Drosophila
|
---|---|
Published in |
Frontiers in immunology, September 2017
|
DOI | 10.3389/fimmu.2017.01151 |
Pubmed ID | |
Authors |
Jie-Jie Sun, Sen Xu, Zhong-Hua He, Xiu-Zhen Shi, Xiao-Fan Zhao, Jin-Xing Wang |
Abstract |
The Toll pathway is essential for inducing an immune response to defend against bacterial invasion in vertebrates and invertebrates. Although Toll receptors and the transcription factor Dorsal were identified in different shrimp, relatively little is known about how the Toll pathway is activated or the function of the pathway in shrimp antibacterial immunity. In this study, three Tolls (Toll1-3) and the Dorsal were identified in Marsupenaeus japonicus. The Toll pathway can be activated by Gram-positive (G(+)) and Gram-negative (G(-)) bacterial infection. Unlike Toll binding to Spätzle in Drosophila, shrimp Tolls could directly bind to pathogen-associated molecular patterns from G(+) and G(-) bacteria, resulting in Dorsal translocation into nucleus to regulate the expression of different antibacterial peptides (AMPs) in the clearance of infected bacteria. These findings suggest that shrimp Tolls are pattern recognition receptors and the Toll pathway in shrimp is different from the Drosophila Toll pathway but identical with the mammalian Toll-like receptor pathway in its activation and antibacterial functions. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 21% |
Researcher | 8 | 19% |
Student > Ph. D. Student | 8 | 19% |
Professor > Associate Professor | 2 | 5% |
Professor | 2 | 5% |
Other | 3 | 7% |
Unknown | 11 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 26% |
Agricultural and Biological Sciences | 11 | 26% |
Immunology and Microbiology | 3 | 7% |
Computer Science | 2 | 5% |
Engineering | 2 | 5% |
Other | 0 | 0% |
Unknown | 14 | 33% |