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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis
|
|---|---|
| Published in |
Frontiers in immunology, November 2017
|
| DOI | 10.3389/fimmu.2017.01386 |
| Pubmed ID | |
| Authors |
Ashish Saroha, Yael Pewzner-Jung, Natalia S. Ferreira, Piyush Sharma, Youenn Jouan, Samuel L. Kelly, Ester Feldmesser, Alfred H. Merrill, François Trottein, Christophe Paget, Karl S. Lang, Anthony H. Futerman |
| Abstract |
The role of sphingolipids (SLs) in the immune system has come under increasing scrutiny recently due to the emerging contributions that these important membrane components play in regulating a variety of immunological processes. The acyl chain length of SLs appears particularly critical in determining SL function. Here, we show a role for very-long acyl chain SLs (VLC-SLs) in invariant natural killer T (iNKT) cell maturation in the thymus and homeostasis in the liver. Ceramide synthase 2-null mice, which lack VLC-SLs, were susceptible to a hepatotropic strain of lymphocytic choriomeningitis virus, which is due to a reduction in the number of iNKT cells. Bone marrow chimera experiments indicated that hematopoietic-derived VLC-SLs are essential for maturation of iNKT cells in the thymus, whereas parenchymal-derived VLC-SLs are crucial for iNKT cell survival and maintenance in the liver. Our findings suggest a critical role for VLC-SL in iNKT cell physiology. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 20% |
| Unknown | 4 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 20% |
| Researcher | 2 | 10% |
| Student > Doctoral Student | 2 | 10% |
| Student > Bachelor | 2 | 10% |
| Student > Postgraduate | 2 | 10% |
| Other | 5 | 25% |
| Unknown | 3 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 5 | 25% |
| Biochemistry, Genetics and Molecular Biology | 4 | 20% |
| Medicine and Dentistry | 3 | 15% |
| Chemistry | 2 | 10% |
| Agricultural and Biological Sciences | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 3 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2020.
All research outputs
#3,232,533
of 25,932,719 outputs
Outputs from Frontiers in immunology
#3,467
of 32,608 outputs
Outputs of similar age
#58,255
of 344,004 outputs
Outputs of similar age from Frontiers in immunology
#72
of 586 outputs
Altmetric has tracked 25,932,719 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 32,608 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,004 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 586 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.