Title |
Induction of Peripheral Tolerance in Ongoing Autoimmune Inflammation Requires Interleukin 27 Signaling in Dendritic Cells
|
---|---|
Published in |
Frontiers in immunology, October 2017
|
DOI | 10.3389/fimmu.2017.01392 |
Pubmed ID | |
Authors |
Rodolfo Thomé, Jason N. Moore, Elisabeth R. Mari, Javad Rasouli, Daniel Hwang, Satoshi Yoshimura, Bogoljub Ciric, Guang-Xian Zhang, Abdolmohamad M. Rostami |
Abstract |
Peripheral tolerance to autoantigens is induced via suppression of self-reactive lymphocytes, stimulation of tolerogenic dendritic cells (DCs) and regulatory T (Treg) cells. Interleukin (IL)-27 induces tolerogenic DCs and Treg cells; however, it is not known whether IL-27 is important for tolerance induction. We immunized wild-type (WT) and IL-27 receptor (WSX-1) knockout mice with MOG35-55 for induction of experimental autoimmune encephalomyelitis and intravenously (i.v.) injected them with MOG35-55 after onset of disease to induce i.v. tolerance. i.v. administration of MOG35-55 reduced disease severity in WT mice, but was ineffective in Wsx-/- mice. IL-27 signaling in DCs was important for tolerance induction, whereas its signaling in T cells was not. Further mechanistic studies showed that IL-27-dependent tolerance relied on cooperation of distinct subsets of spleen DCs with the ability to induce T cell-derived IL-10 and IFN-γ. Overall, our data show that IL-27 is a key cytokine in antigen-induced peripheral tolerance and may provide basis for improvement of antigen-specific tolerance approaches in multiple sclerosis and other autoimmune diseases. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 33% |
Student > Bachelor | 3 | 9% |
Student > Doctoral Student | 3 | 9% |
Researcher | 3 | 9% |
Student > Master | 2 | 6% |
Other | 4 | 12% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 8 | 24% |
Medicine and Dentistry | 5 | 15% |
Agricultural and Biological Sciences | 5 | 15% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Unspecified | 1 | 3% |
Other | 3 | 9% |
Unknown | 8 | 24% |