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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Macrophage Autophagy and Bacterial Infections
|
|---|---|
| Published in |
Frontiers in immunology, November 2017
|
| DOI | 10.3389/fimmu.2017.01483 |
| Pubmed ID | |
| Authors |
Aïcha Bah, Isabelle Vergne |
| Abstract |
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. One of the most studied is probably xenophagy, the selective capture and degradation of intracellular bacteria by lysosomes. However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. In addition, autophagy machinery can have non-canonical functions such as LC3-associated phagocytosis. In this review, we intend to summarize the current knowledge on the many functions of autophagy proteins in cell defenses with a focus on bacteria-macrophage interaction. We also present the strategies developed by pathogens to evade or to exploit this machinery in order to establish a successful infection. Finally, we discuss the opportunities and challenges of autophagy manipulation in improving therapeutics and vaccines against bacterial pathogens. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 17% |
| Netherlands | 1 | 17% |
| France | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 148 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 28 | 19% |
| Student > Master | 20 | 14% |
| Student > Bachelor | 15 | 10% |
| Researcher | 14 | 9% |
| Student > Postgraduate | 5 | 3% |
| Other | 16 | 11% |
| Unknown | 50 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 37 | 25% |
| Immunology and Microbiology | 20 | 14% |
| Agricultural and Biological Sciences | 16 | 11% |
| Medicine and Dentistry | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
| Other | 9 | 6% |
| Unknown | 52 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2018.
All research outputs
#7,896,805
of 25,932,719 outputs
Outputs from Frontiers in immunology
#9,149
of 32,608 outputs
Outputs of similar age
#118,240
of 345,604 outputs
Outputs of similar age from Frontiers in immunology
#218
of 604 outputs
Altmetric has tracked 25,932,719 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 32,608 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,604 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 604 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.