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Checks and Balances in Autoimmune Vasculitis

Overview of attention for article published in Frontiers in immunology, February 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (71st percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

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6 X users
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4 patents

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Title
Checks and Balances in Autoimmune Vasculitis
Published in
Frontiers in immunology, February 2018
DOI 10.3389/fimmu.2018.00315
Pubmed ID
Authors

Rebeca Hid Cadena, Wayel H. Abdulahad, G. A. P. Hospers, T. T. Wind, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer

Abstract

Age-associated changes in the immune system including alterations in surface protein expression are thought to contribute to an increased susceptibility for autoimmune diseases. The balance between the expression of coinhibitory and costimulatory surface protein molecules, also known as immune checkpoint molecules, is crucial in fine-tuning the immune response and preventing autoimmunity. The activation of specific inhibitory signaling pathways allows cancer cells to evade recognition and destruction by the host immune system. The use of immune checkpoint inhibitors (ICIs) to treat cancer has proven to be effective producing durable antitumor responses in multiple cancer types. However, one of the disadvantages derived from the use of these agents is the appearance of inflammatory manifestations termed immune-related adverse events (irAEs). These irAEs are often relatively mild, but more severe irAEs have been reported as well including several forms of vasculitis. In this article, we argue that age-related changes in expression and function of immune checkpoint molecules lead to an unstable immune system, which is prone to tolerance failure and autoimmune vasculitis development. The topic is introduced by a case report from our hospital describing a melanoma patient treated with ICIs and who subsequently developed biopsy-proven giant cell arteritis. Following this case report, we present an in-depth review on the role of immune checkpoint pathways in the development and progression of autoimmune vasculitis and its relation with an aging immune system.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 13%
Student > Bachelor 8 13%
Student > Ph. D. Student 7 11%
Other 6 10%
Student > Master 5 8%
Other 13 21%
Unknown 15 24%
Readers by discipline Count As %
Medicine and Dentistry 24 39%
Biochemistry, Genetics and Molecular Biology 4 6%
Immunology and Microbiology 4 6%
Business, Management and Accounting 3 5%
Agricultural and Biological Sciences 2 3%
Other 8 13%
Unknown 17 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2023.
All research outputs
#5,702,316
of 26,414,132 outputs
Outputs from Frontiers in immunology
#6,509
of 33,172 outputs
Outputs of similar age
#98,829
of 348,268 outputs
Outputs of similar age from Frontiers in immunology
#183
of 676 outputs
Altmetric has tracked 26,414,132 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 33,172 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 348,268 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 676 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.