Title |
Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation
|
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Published in |
Frontiers in immunology, April 2018
|
DOI | 10.3389/fimmu.2018.00804 |
Pubmed ID | |
Authors |
Carlos del Fresno, Salvador Iborra, Paula Saz-Leal, María Martínez-López, David Sancho |
Abstract |
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which lead to integration of heterologous signaling among diverse receptors. Herein, we will review how sensing by myeloid CLRs and crosstalk with heterologous receptors is modulated by many factors affecting their signaling and resulting in differential outcomes for immunity and inflammation. Finding common features among those flexible responses initiated by diverse CLR-ligand partners will help to harness CLR function in immunity and inflammation. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 75% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 129 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 25% |
Researcher | 18 | 14% |
Student > Master | 12 | 9% |
Student > Bachelor | 9 | 7% |
Other | 8 | 6% |
Other | 17 | 13% |
Unknown | 33 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 27 | 21% |
Biochemistry, Genetics and Molecular Biology | 22 | 17% |
Agricultural and Biological Sciences | 20 | 16% |
Chemistry | 6 | 5% |
Medicine and Dentistry | 5 | 4% |
Other | 14 | 11% |
Unknown | 35 | 27% |