Title |
Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System
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Published in |
Frontiers in immunology, May 2018
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DOI | 10.3389/fimmu.2018.01094 |
Pubmed ID | |
Authors |
Manuel D. Díaz-Muñoz, Martin Turner |
Abstract |
Fighting external pathogens requires an ever-changing immune system that relies on tight regulation of gene expression. Transcriptional control is the first step to build efficient responses while preventing immunodeficiencies and autoimmunity. Post-transcriptional regulation of RNA editing, location, stability, and translation are the other key steps for final gene expression, and they are all controlled by RNA-binding proteins (RBPs). Nowadays we have a deep understanding of how transcription factors control the immune system but recent evidences suggest that post-transcriptional regulation by RBPs is equally important for both development and activation of immune responses. Here, we review current knowledge about how post-transcriptional control by RBPs shapes our immune system and discuss the perspective of RBPs being the key players of a hidden immune cell epitranscriptome. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 29% |
Singapore | 1 | 14% |
Switzerland | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 43% |
Scientists | 3 | 43% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 151 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 42 | 28% |
Researcher | 24 | 16% |
Student > Bachelor | 18 | 12% |
Student > Master | 16 | 11% |
Student > Postgraduate | 6 | 4% |
Other | 12 | 8% |
Unknown | 33 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 55 | 36% |
Agricultural and Biological Sciences | 23 | 15% |
Immunology and Microbiology | 18 | 12% |
Computer Science | 3 | 2% |
Neuroscience | 3 | 2% |
Other | 14 | 9% |
Unknown | 35 | 23% |