Title |
Potential Immunological Links Between Psoriasis and Cardiovascular Disease
|
---|---|
Published in |
Frontiers in immunology, June 2018
|
DOI | 10.3389/fimmu.2018.01234 |
Pubmed ID | |
Authors |
Aparna P. Sajja, Aditya A. Joshi, Heather L. Teague, Amit K. Dey, Nehal N. Mehta |
Abstract |
Preclinical and clinical research provide strong evidence that chronic, systemic inflammation plays a key role in development and progression of atherosclerosis. Indeed, chronic inflammatory diseases, such as psoriasis, are associated with accelerated atherosclerosis and increased risk of cardiovascular events. Contemporary research has demonstrated plausible mechanistic links between immune cell dysfunction and cardiometabolic disease in psoriasis. In this review, we describe the role of potential common immunological mechanisms underlying both psoriasis and atherogenesis. We primarily discuss innate and adaptive immune cell subsets and their contributions to psoriatic disease and cardiovascular morbidity. Emerging efforts should focus on understanding the interplay among immune cells, adipose tissue, and various biomarkers of immune dysfunction to provide direction for future targeted therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Spain | 1 | 17% |
Singapore | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Practitioners (doctors, other healthcare professionals) | 3 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 77 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 17% |
Student > Master | 9 | 12% |
Other | 8 | 10% |
Student > Ph. D. Student | 6 | 8% |
Student > Postgraduate | 4 | 5% |
Other | 16 | 21% |
Unknown | 21 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 39% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Agricultural and Biological Sciences | 3 | 4% |
Immunology and Microbiology | 3 | 4% |
Other | 7 | 9% |
Unknown | 25 | 32% |