Title |
Invariant Natural Killer T Cell Subsets—More Than Just Developmental Intermediates
|
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Published in |
Frontiers in immunology, June 2018
|
DOI | 10.3389/fimmu.2018.01393 |
Pubmed ID | |
Authors |
S. Harsha Krovi, Laurent Gapin |
Abstract |
Invariant natural killer T (iNKT) cells are a CD1d-restricted T cell population that can respond to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines. This broad functional scope has placed iNKT cells at the frontlines of many kinds of immune responses. Although the diverse functional capacities of iNKT cells have long been acknowledged, only recently have distinct iNKT cell subsets, each with a marked functional predisposition, been appreciated. Furthermore, the subsets can frequently occupy distinct niches in different tissues and sometimes establish long-term tissue residency where they can impact homeostasis and respond quickly when they sense perturbations. In this review, we discuss the developmental origins of the iNKT cell subsets, their localization patterns, and detail what is known about how different subsets specifically influence their surroundings in conditions of steady and diseased states. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 197 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 41 | 21% |
Student > Bachelor | 24 | 12% |
Researcher | 23 | 12% |
Student > Master | 22 | 11% |
Student > Doctoral Student | 11 | 6% |
Other | 18 | 9% |
Unknown | 58 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 59 | 30% |
Biochemistry, Genetics and Molecular Biology | 31 | 16% |
Medicine and Dentistry | 16 | 8% |
Agricultural and Biological Sciences | 16 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Other | 10 | 5% |
Unknown | 60 | 30% |